College football betting lines: Ole Miss-Georgia, Tennessee-Alabama lead Top 25 matchups

There are five ranked matchups in college football this weekend, the most in any week this season. Three of them are in the SEC -- tying the conference record for the most in one week -- with No. 10 LSU taking on No. 17 Vanderbilt, No. 5 Ole Miss at No. 9 Georgia, and No. 11 Tennessee taking on No. 6 Alabama, all on ABC.

No. 20 USC will face its longtime rival No. 13 Notre Dame. The Big 12 will feature No. 23 Utah taking on in-state rival No. 15 BYU. Notre Dame and No. 23 Texas are the only two-loss teams in the rankings.

BYU is up to its highest ranking of the season, No. 12 Georgia Tech (at Duke) is up to its highest since 2014, No. 4 Texas A&M (at Arkansas) is up to its highest in 30 years, according to ESPN Research.

Most notably, No. 3 Indiana is up to its best ranking ever after beating Oregon in Eugene. Oregon slips to No. 8 and will look to right the ship against Rutgers on Saturday.

See more: Power Rankings | Betting Buzz

All times Eastern. For latest lines, go to ESPN BET 

Louisville at No. 2 Miami -13.5
Friday, 7 p.m., ESPN

Records: Louisville 4-1, 0-1 vs. AP teams; Miami 5-0, 3-0 vs. AP teams
Opening Line: Miami -13.5, O/U 54.5
Money line: Louisville (+400); Miami (-600)
Over/Under: 49.5 (O -115, U -105)


FPI Projection Miami by 12.5 points with a 85% probability to win game outright

No. 25 Nebraska -7.5 at Minnesota
Friday, 8 p.m., FOX

Records: Nebraska 5-1, 0-1 vs. AP teams; Minnesota 4-2, 0-1 vs. AP teams
Opening Line: Nebraska -5.5, O/U 47.5
Money line: Nebraska (-280); Minnesota (+230)
Over/Under: 47.5 (O -115, U -105)


FPI Projection Nebraska by 7.3 points with a 76% probability to win game outright

No. 10 LSU at No. 17 Vanderbilt -2.5
Saturday, Noon, ABC

Records: LSU 5-1, 1-1 vs. AP teams; Vanderbilt 5-1, 1-1 vs. AP teams
Opening Line: Vanderbilt -2.5, O/U 48.5
Money line: LSU (+120); Vanderbilt (-140)
Over/Under: 48.5 (O -115, U -105)


FPI Projection Vanderbilt by 2.5 points with a 61% probability to win game outright

No. 12 Georgia Tech at Duke -1.5
Saturday, Noon, ESPN

Records: Georgia Tech 6-0, 1-0 vs. AP teams; Duke 4-2, 0-1 vs. AP teams
Opening Line: Duke -2.5, O/U 60.5
Money line: Georgia Tech (+105); Duke (-125)
Over/Under: 60.5 (O -110, U -110)


FPI Projection Duke by 3.1 points with a 62% probability to win game outright

No. 14 Oklahoma -5.5 at South Carolina
Saturday, 12:45 p.m., SEC Network

Records: Oklahoma 5-1, 2-0 vs. AP teams; South Carolina 3-3, 0-2 vs. AP teams
Opening Line: Oklahoma -4.5, O/U 42.5
Money line: Oklahoma (-210); South Carolina (+175)
Over/Under: 43.5 (O EVEN, U -120)


FPI Projection Oklahoma by 1.1 points with a 55% probability to win game outright

No. 1 Ohio State -25.5 at Wisconsin
Saturday, 3:30 p.m., CBS

Records: Ohio State 6-0, 2-0 vs. AP teams; Wisconsin 2-4, 0-2 vs. AP teams
Opening Line: Ohio State -26.5, O/U 41.5
Money line: Off
Over/Under: 41.5 (O -105, U -115)


FPI Projection Ohio State by 23.3 points with a 95% probability to win game outright

Michigan State at No. 3 Indiana -27.5
Saturday, 3:30 p.m., Peacock

Records: Michigan State 3-3, 0-1 vs. AP teams; Indiana 6-0, 2-0 vs. AP teams
Opening Line: Indiana -26.5, O/U 54.5
Money line: Off
Over/Under: 50.5 (O -120, U EVEN)


FPI Projection Indiana by 27 points with a 96% probability to win game outright

No. 4 Texas A&M -7.5 at Arkansas
Saturday, 3:30 p.m., ESPN

Records: Texas A&M 6-0, 1-0 vs. AP teams; Arkansas 2-4, 0-3 vs. AP teams
Opening Line: Texas A&M -7.5, O/U 62.5
Money line: Texas A&M (-300); Arkansas (+250)
Over/Under: 58.5 (O -110, U -110)


FPI Projection Texas A&M by 5.2 points with a 70% probability to win game outright

No. 5 Ole Miss at No. 9 Georgia -7.5
Saturday, 3:30 p.m., ABC

Records: Ole Miss 6-0, 1-0 vs. AP teams; Georgia 5-1, 1-1 vs. AP teams
Opening Line: Georgia -6.5, O/U 54.5
Money line: Ole Miss (+230); Georgia (-280)
Over/Under: 57.5 (O -105, U -115)


FPI Projection Georgia by 5.3 points with a 70% probability to win game outright

No. 7 Texas Tech -7.5 at Arizona State
Saturday, 4 p.m., FOX

Records: Texas Tech 6-0, 1-0 vs. AP teams; Arizona State 4-2, 1-0 vs. AP teams
Line Movement Alert: Opened Texas Tech -10.5, O/U 49.5
Money line: Texas Tech (-290); Arizona State (+240)
Over/Under: 51.5 (O -110, U -110)


FPI Projection Texas Tech by 7.4 points with a 76% probability to win game outright

No. 22 Memphis -21.5 at UAB
Saturday, 4 p.m., ESPN2

Records: Memphis 6-0, 0-0 vs. AP teams; UAB 2-4, 0-1 vs. AP teams
Opening Line: Memphis -21.5, O/U 64.5
Money line: Memphis (-2000); UAB (+1000)
Over/Under: 62.5 (O -110, U -110)


FPI Projection Memphis by 25.7 points with a 96% probability to win game outright

No. 8 Oregon -17.5 at Rutgers
Saturday, 6:30 p.m., BTN

Records: Oregon 5-1, 1-1 vs. AP teams; Rutgers 3-3, 0-0 vs. AP teams
Opening Line: Oregon -15.5, O/U 59.5
Money line: Oregon (-1000); Rutgers (+600)
Over/Under: 61.5 (O EVEN, U -120)


FPI Projection Oregon by 11.6 points with a 84% probability to win game outright

Washington State at No. 18 Virginia -17.5
Saturday, 6:30 p.m., The CW Network

Records: Washington State 3-3, 0-1 vs. AP teams; Virginia 5-1, 1-0 vs. AP teams
Opening Line: Virginia -16.5, O/U 57.5
Money line: Washington State (+700); Virginia (-1200)
Over/Under: 55.5 (O -115, U -105)


FPI Projection Virginia by 18.8 points with a 92% probability to win game outright

No. 21 Texas -13.5 at Kentucky
Saturday, 7 p.m., ESPN

Records: Texas 4-2, 1-1 vs. AP teams; Kentucky 2-3, 0-2 vs. AP teams
Opening Line: Texas -12.5, O/U 43.5
Money line: Texas (-550); Kentucky (+380)
Over/Under: 43.5 (O -115, U -105)


FPI Projection Texas by 10.5 points with a 82% probability to win game outright

No. 11 Tennessee at No. 6 Alabama -8.5
Saturday, 7:30 p.m., ABC

Records: Tennessee 5-1, 0-1 vs. AP teams; Alabama 5-1, 3-0 vs. AP teams
Opening Line: Alabama -8.5, O/U 58.5
Money line: Tennessee (+260); Alabama (-320)
Over/Under: 59.5 (O EVEN, U -120)


FPI Projection Alabama by 6.2 points with a 73% probability to win game outright

No. 20 USC at No. 13 Notre Dame -9.5
Saturday, 7:30 p.m., NBC, Peacock

Records: USC 5-1, 1-1 vs. AP teams; Notre Dame 4-2, 0-2 vs. AP teams
Opening Line: Notre Dame -7.5, O/U 61.5
Money line: USC (+270); Notre Dame (-340)
Over/Under: 60.5 (O -115, U -105)


FPI Projection Notre Dame by 4.9 points with a 69% probability to win game outright

Florida Atlantic at No. 19 South Florida -21.5
Saturday, 7:30 p.m., ESPNU

Records: Florida Atlantic 3-3, 0-0 vs. AP teams; South Florida 5-1, 2-1 vs. AP teams
Opening Line: South Florida -22.5, O/U 74.5
Money line: Florida Atlantic (+1000); South Florida (-2000)
Over/Under: 72.5 (O -120, U EVEN)


FPI Projection South Florida by 19.3 points with a 92% probability to win game outright

No. 16 Missouri at Auburn -1.5
Saturday, 7:45 p.m., SEC Network

Records: Missouri 5-1, 0-1 vs. AP teams; Auburn 3-3, 0-3 vs. AP teams
Opening Line: Auburn -2.5, O/U 44.5
Money line: Missouri (-125); Auburn (+105)
Over/Under: 43.5 (O -120, U EVEN)


FPI Projection Missouri by 0.8 points with a 54% probability to win game outright

No. 23 Utah -3.5 at No. 15 BYU
Saturday, 8 p.m., FOX

Records: Utah 5-1, 1-1 vs. AP teams; BYU 6-0, 0-0 vs. AP teams
Opening Line: Utah -3.5, O/U 47.5
Money line: Utah (-165); BYU (+140)
Over/Under: 49.5 (O -105, U -115)


FPI Projection BYU by 0.3 points with a 51% probability to win game outright

No. 24 Cincinnati -21.5 at Oklahoma State
Saturday, 8 p.m., ESPN2

Records: Cincinnati 5-1, 1-0 vs. AP teams; Oklahoma State 1-5, 0-1 vs. AP teams
Opening Line: Cincinnati -20.5, O/U 57.5
Money line: Cincinnati (-2500); Oklahoma State (+1100)
Over/Under: 57.5 (O -120, U EVEN)


FPI Projection Cincinnati by 18 points with a 91% probability to win game outright